Vorläufige Notiz über Colchicum

Colchicum Ad Nauseum

A 39-year-old man was admitted to hospital because of vomiting and diarrhoea. He had developed cardiomyopathy of unknown cause a decade earlier that was managed with diuretics and an angiotensin-converting enzyme inhibitor. Two years thereafter, insulindependent diabetes mellitus appeared. His HbA1c was controlled at 7.5%. Two weeks prior to admission, he developed a burning pain in both feet. ...

Case report: fatal poisoning with Colchicum autumnale

INTRODUCTION Colchicum autumnale, commonly known as the autumn crocus, contains alkaloid colchicine with antimitotic properties. CASE REPORT A 76-year-old man with a history of alcoholic liver disease and renal insufficiency, who mistakenly ingested Colchicum autumnale instead of wild garlic (Aliium ursinum), presented with nausea, vomiting and diarrhea 12 hours after ingestion. On admission ...

Biosynthesis of the indole and Colchicum alkaloids.

There has been enormous progress over the past fifteen years or so in our understanding of the ways in which complex natural products are synthesized in living systems. In the field of alkaloids, as elsewhere, research during the initial phase1 pin-pointed those substances which are used as the common building blocks, examples being acetic acid, ornithine and lysine for the reduced systems, and...

Suicidal plant poisoning with Colchicum autumnale.

Colchicum autumnale is commonly known as autumn crocus, and as 'gowri gedde' in the southern region of Karnataka State in South India. It contains an alkaloid called colchicine, which blocks the cell division by inhibiting mitosis. We present a sporadic case of suicidal plant poisoning wherein a 24-year-old man consumed 'gowri gedde' to end his life. Initially he presented with severe vomiting,...

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